The factor that could influence future breast cancer treatment -Breast ...

? Breast Cancer news ? Dec 29, 2012

Australian scientists have shown in the laboratory how a ?transcription factor? causes breast cancer cells to develop an aggressive subtype that lacks sensitivity to estrogen and does not respond to known anti-estrogen therapies. The research, which has significant implications for breast cancer treatment, is published December 27 in the open access journal PLOS Biology.

Transcription factors are molecules that switch genes on or off. In this case, the transcription factor known as ?ELF5? inhibits sensitivity to estrogen very early in the life of a breast cancer cell. In 2008, Professor Chris Ormandy from the Garvan Institute of Medical Research in Sydney, Australia, showed that ELF5 was responsible for the development of breast progenitor cells into the estrogen-receptor-negative cells that produce milk in the breast during pregnancy.

In the current study, a team led by Ormandy in collaboration with Drs Maria Kalyga and David Gallego-Ortega, has shown that the same molecular decision occurs in breast cancer and that ELF5 has the ability to change an existing tumour into an estrogen-insensitive tumour.

?This work tells us that cancers which become refractory to anti-estrogen treatment often do so by elevating their levels of ELF5 and becoming functionally estrogen receptor negative,? said Ormandy.

The team has also described the genetic mechanisms by which ELF5 opposes the action of estrogen, and has shown that it is possible to alter the subtype of breast cancer by manipulating ELF5 levels in cancer cells in the laboratory.

?This raises the therapeutic option of manipulating ELF5 levels to treat breast cancer. As ELF5 is intracellular, this could possibly be done with small molecule therapies that penetrate cells and target protein-to-protein interactions, or with small inhibitory RNAs. There is also the possibility of testing ELF5 levels in tumours to predict response to treatment and therefore guide treatment decisions.?

?Our key discovery here is that by simply manipulating one transcription factor we can change the subtype of breast cancer.?
###

Funding: This work was funded by The National Health and Medical Research Council of Australia, New South Wales Cancer Council, Cancer Institute New South Wales, Banque Nationale de Paris-Paribas Australia and New Zealand, RT Hall Trust, Australian Cancer Research Foundation, Prostate Cancer Foundation Australia, Cure Cancer Foundation Australia, Breast Cancer Campaign UK, and the National Breast Cancer Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing interests: The authors have declared that no competing interests exist.

Citation: Kalyuga M, Gallego-Ortega D, Lee HJ, Roden DL, Cowley MJ, et al. (2012) ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer. PLoS Biol 10(12): e1001461. doi:10.1371/journal.pbio.1001461

CONTACT:
Christopher Ormandy
Garvan Institute
Sydney, AUSTRALIA

###

Bryan Ghosh
44-122-344-2837
Public Library of Science

Provided by ArmMed Media

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Source: http://www.health.am/cr/more/influence-future-breast-cancer-treatment/

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Stock futures edge higher as "cliff" talks continue

(Reuters) - Equity futures were slightly higher on Sunday night as talks continued in Washington over resolving the "fiscal cliff."

While the Senate will not vote Sunday night on any bill to avoid a series of $600 billion in tax hikes and spending cuts, as many had hoped, negotiations continued between lawmakers and the White House.

The Senate will reconvene on Monday after the open of equity trading. In order for a deal to take effect, it would also have to be passed by the House of Representatives.

Despite the gain indicated by futures, stocks still could end up falling on Monday when the cash markets open if lawmakers are unable to come to an agreement to avoid the cliff, which many fear could push the economy into recession.

"There is always a chance for a massive stalemate, and we could see a lot more volatility if we get to a point where there's no more hope. Right now there's still hope," said Adam Sarhan, chief executive of Sarhan Capital in New York.

Midnight on Monday marks the deadline for a deal, though the government can pass legislation in 2013 that retroactively prevents going over the cliff, an option that is viewed as politically easier.

"At some point, someone will have to blink, or Congress will just come in early in 2013 and vote for a tax cut," Sarhan said. "Something will be done to resolve this."

S&P 500 futures were up 5.4 points, or 0.4 percent, at 1,389 in electronic trading. Still, futures were about 7 points below the fair value level of 1,397.19. Fair value is a formula that evaluates pricing by taking into account interest rates, dividends and time to expiration on the contract. Despite the rise, if futures remain below fair value, cash markets will open lower.

Dow and Nasdaq futures were also slightly higher, though below fair value.

Stocks fell sharply on Friday, with significant losses in the last minutes of trading, as prospects for a deal worsened at the beginning of the weekend.

The rise in the futures market does not necessarily augur for a rally on Monday, however. The cash market and futures markets closed with a wide gulf on Friday, by virtue of the extra 15 minutes of trading in futures.

The S&P 500 closed at 1,402.43 at 4 p.m. ET on Friday, down 1.1 percent, but futures continued to fall before closing 15 minutes later with a loss of 1.9 percent. S&P futures and the S&P cash index don't match point-by-point, but that kind of disparity points to a weak opening in stocks on Monday.

One hour before they had hoped to present a plan on Sunday, Democratic and Republican Senate leaders said they were still unable to reach a compromise.

Earlier in the day, President Barack Obama, appearing on NBC's "Meet the Press," said investors could begin to show greater concerns in the new year.

"If people start seeing that on January 1st this problem still hasn't been solved ... then obviously that's going to have an adverse reaction in the markets," he said,

Investors have remained relatively sanguine about the process, believing that it will eventually be solved. In the past two months markets have not shown the kind of volatility that was present during the fight to raise the debt ceiling in 2011.

The Dow industrials and the S&P 500 each lost 1.9 percent last week, after stocks fell for five straight sessions, which marked the S&P 500's longest losing streak in three months. Equities have largely performed well in the last two months despite constant chatter about the fiscal cliff, but the last few days shows a bit of increased worry.

The CBOE Volatility Index <.vix> rose to its highest level since June on Friday, closing at 22.72.

(Additional reporting by David Gaffen; Editing by Jan Paschal)

Source: http://news.yahoo.com/stock-futures-edge-higher-cliff-talks-continue-004506710--sector.html

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Petition the Debt Star on ObamaCare, Feinstein

Dec 30 2012

Why shouldn?t our rulers share in the blessings they bestow upon us? Just as Obama et al. should be protected by gun-free zones, the entire nomenklatura deserves to be graced with ObamaCare. If you agree, you can sign the petition:

Mandatory Inclusion of All Politicians and Their Families in the Affordable Health Care Act Provisions

Congress has exempted itself from provisions of the Affordable Health Care Act. If the provisions of this act were designed to benefit the American people and mandatory participation is required of the ordinary public, politicians in Congress should not be exempt.

Speaking of petitions, here?s another good one:

Try Senator Dianne Feinstein in a Federal Court for Treason to the Constitution

The Constitution was written to restrain the government. No amendment is more important for this purpose than the 2nd amendment. The 2nd amendment was written so the power could be kept with the citizenry in the face of a tyrannical government. It was well understood the Constitution acknowledged certain rights that could not be limited by government.

Senator Dianne Feinstein has made it clear she does not believe in the Constitution or the inalienable rights of Americans to keep and bear arms. She is actively working to destroy the 2nd amendment with her 2013 assault weapons ban. For this reason we the people of the United States petition for her to be tried in Federal Court for treason to the Constitution.

White House petitions won?t sway our rulers, but at least we can put it on the record that what liberals are doing to our country is being done against our will.

On tips from Steve A, IslandLifer, and G. Fox.

Source: http://moonbattery.com/?p=23236

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Volunteer Sessions Begin For 2015 Canada Winter Games

Volunteer Sessions Begin For 2015 Canada Winter Games

By 250 News

Sunday, December 30, 2012 05:10 AM

Volunteer recruitment sessions have begun at Canada Games House on Quebec Street

Prince George, BC - 774 days and counting until Prince George hosts the 2015 Canada Winter Games...

With the countdown clock on the Games' webpage quietly ticking down, volunteer recruitment efforts are ramping up.? The Canada Games House on Quebec Street hosted a number of volunteer recruitment sessions earlier this month that saw more than 60 people attend.

More sessions are being held mid-January - the 14th, 15th, and 16th - with anyone interested being asked to RSVP by emailing volunteer@canadagames2015.ca, or phoning 250-596-2015 when the office re-opens on January 2nd.

It's expected that as many as 4500 volunteers will be needed to host the largest multi-sporting and cultural event ever held in our region, from February 13th until March 1st, 2015.

The 2015 Games Host Society is also seeking input from athletes from across the region who will be eligible to compete in a bid to meet its top priority of providing an 'exceptional athlete experience'.? Click here to submit an application for the Athlete Approved Advisory Group.

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Posted on Sunday, December 30, 2012 05:10 AM in News by 250 News
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Source: http://www.250news.com/blog/view/26964/1/volunteer+sessions+begin+for+2015+canada+winter+games

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Tax portion of fiscal cliff deal reportedly has been finalized (Powerlineblog)

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Chinese boat detained after fishing in Japanese waters

Tokyo, (IANS) The Japanese Coast Guard has detained a Chinese fishing boat for allegedly fishing in the country?s exclusive economic zone without authorisation, Xinhua reported Sunday.

The Chinese consulate general in Fukuoka said the boat, which belongs to Fujian province, was seized around 10 p.m. Saturday near Japan?s Kagoshima prefecture with its captain and eight crew members on board.

All the crew members are Chinese nationals, the consulate general said.

The captain, who admitted that his boat had entered Japanese waters, and two crew members have been taken for questioning.

China has asked Japan to ensure the safety and legitimate rights of the sailors.

Shortlink:

Posted by admin on December 31, 2012. Filed under Business, world. You can follow any responses to this entry through the RSS 2.0. You can leave a response or trackback to this entry

Source: http://nvonews.com/2012/12/31/chinese-boat-detained-after-fishing-in-japanese-waters/

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Oglala Sioux Tribe President Injured In Car Wreck

RAPID CITY, SD -

The newly elected president of the Oglala Sioux Tribe has been injured in a one-vehicle wreck on the Pine Ridge Indian Reservation in western South Dakota.

Bryan Brewer's administrative assistant says the cause of the Saturday night wreck is so far unknown.

Angie Sam says Brewer is still "pretty heavily medicated."

Reports say that Brewer suffered cuts to his head and a broken hip, but Sam says it was a clean break and the president is expected to make a fast recovery.

Brewer is being treated at the Rapid City Regional Hospital.

The wreck was near Red Shirt Table.

Sam says the injuries won't sideline Brewer's ability to fulfill his presidential duties for the tribe, though some meetings will need to be rescheduled.

? 2012 Associated Press. All rights reserved. Material may not be redistributed.

Source: http://www.keloland.com/newsdetail.cfm/oglala-sioux-tribe-president-injured-in-car-wreck/?id=141832

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Denmark Township: An eye for birds, and a legacy in nature ...

Jim Fitzpatrick, pictured in 2005, is one of a handful of people who claim a sighting of the rare ivory-billed woodpecker. (Pioneer Press file)

Jim Fitzpatrick's two loves -- bird watching and the St. Croix River -- are clearly visible at his office at the Carpenter-St. Croix Valley Nature Center in Denmark Township.

The windows look out over the river. The bookshelves and walls are filled with birds -- stuffed, mounted, framed -- and photos of the late legendary bird bander Jane Olyphant.

It was Olyphant, a longtime family friend, who sparked Fitzpatrick's interest in bird banding as a young boy. Olyphant would often come to the Fitzpatrick house in North Oaks to band birds; she fastened tiny aluminum bracelets on 84,000 birds during her lifetime.

"We did mostly robins and blue jays and chickadees," Fitzpatrick said. "She got excited when she caught purple martins and tree swallows. Then one day, when she was taking the nets down, a woodcock flew into the net -- and I think she was in heaven."

Fitzpatrick, 64, who lives in Denmark Township and has served on the town board, is retiring Jan. 4. He has been the nature center's executive director since 1981, when he persuaded the Thomas & Edna Carpenter Foundation to transform a 300-acre private estate and apple orchard into a nature center.

"They wanted someone to be a part-time manager for an apple orchard and do programs on the side, and I said, 'Let's turn it around,' " said Fitzpatrick, who at the time was a naturalist at the Dodge Nature Center in West St. Paul. "I basically copied Dodge's program and brought it out here. We tweaked a few

things and went to the school districts, and they loved it."

Carpenter now boasts 725 acres on campuses in Minnesota and Wisconsin and serves more than 100 schools and 10,000 students annually, in addition to offering interpretive public programs and seasonal special events. Many of the programs have to do with bird banding; 195 species of birds have been spotted at Carpenter.

Birds are markers for environmental problems, Fitzpatrick says. "They're important because they are, literally, the canary in the coal mine," he said. "They are telling us that we are doing something wrong."

AN EYE FOR BIRDS

Fitzpatrick, a wildlife biologist, knows his birds. He is one of a handful of people who have reported seeing an ivory-billed woodpecker, a bird thought extinct until Fitzpatrick and others reported sightings in Arkansas in 2004. His younger brother, John, is director of the Cornell Laboratory of Ornithology in New York and has been the leading figure in the search for ivory-billed woodpeckers.

In March 2004, at his brother's invitation, Jim Fitzpatrick was a volunteer helping with the search effort in the White River and Cache River national wildlife refuges in Arkansas. An expert canoeist, Jim had traveled to Arkansas with two canoes to help ferry cameramen and other researchers to remote areas of the river bottoms.

One day, he dropped off a cameraman and struck off on his own for three hours, exploring a tributary of the White River. That's when he spotted the bird while reaching for his lunch.

"I had three cameras in my day pack and a sandwich in my hand," he said.

Although there have been no recent sightings and one of the nation's best-known birders, David Sibley, disputed the identification, Fitzpatrick said he knows what he saw.

"They can have their opinion, and I have mine," he said. "It's very, very hard to misidentify that bird."

Fitzpatrick said he was able to make a positive identification because of the bird's unique white patterns on its wings, its massive size and distinctive flight pattern.

"The white stood out. It was like a billboard," he said. "An ivory-bill (woodpecker) is 20 percent larger and 40 percent heavier than a pileated (woodpecker). With a body like that, the wings can't flap like a woodpecker does. They flap like a loon or a wood duck. There's no up and down. He doesn't have enough versatility to do that. He has to fly."

NATIONAL EXPERT

Fitzpatrick is considered a leading authority on wildlife rehabilitation and the use of captive wildlife in interpretive programming. Earlier this year, he was named Master Interpretive Manager for 2012 by the National Association for Interpretation.

"Jim's influence goes well beyond Carpenter and actually goes out to the whole natural resources and interpretive world," said Randy Thoreson, an outdoor recreation planner for the National Park Service. "He's known throughout the St. Croix River Valley, the Midwest, even nationally."

During his tenure at Carpenter, Fitzpatrick oversaw fundraising campaigns for a new visitors center, orchard building and pavilion. He also served on the town board and the boards of the St. Croix River Association, the Minnesota Conservation Corps, the Minnesota-Wisconsin Boundary Area Commission and the Minnesota Naturalist Association.

"He's been a dynamic and endearing leader who's connected people all across the community to nature," said Jennifer Vieth, Carpenter's director of development and interim executive director. "Anyone who has interacted with Jim has a huge soft spot for him. He makes people feel comfortable about asking questions about nature -- whether it's a group of young people or a group of senior banders. He's got incredible patience for teaching the different intricacies of bird identification and bird banding."

Although he's retiring, Fitzpatrick said he plans to continue to help Carpenter develop the 300 acres of riverfront land it owns in Troy Township, Wis.

He also plans to stay involved in St. Croix River issues. His family owns a place on the river just north of William O'Brien State Park, and he's been a self-proclaimed "river rat" since he was a toddler.

"I think the people who live here don't really grasp the meaning of the Wild and Scenic Rivers Act," he said. "The St. Croix river is one of those unique treasures that the country holds. We need to do all we can to protect it."

Mary Divine can be reached at 651-228-5443. Follow her at twitter.com/MaryEDivine.

IF YOU GO

A retirement open house for Jim Fitzpatrick, executive director of the Carpenter-St. Croix Valley Nature Center, will be from 2 to 6 p.m. Friday, Jan. 4, at the nature center in Denmark Township. For information, call 651-437-4359.

Source: http://www.twincities.com/localnews/ci_22275492/denmark-township-an-eye-birds-and-legacy-nature?source=rss

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Microsoft investigating new IE vulnerability used in targeted attacks, IE9 and IE10 users are safe

Criminals are using a new Internet Explorer security hole to attack Windows computers in targeted attacks, though the vulnerability could end up being more widely exploited. While IE9 and IE10 are not affected, versions IE6, IE7, and IE8 are. It?s great to see that the latest versions of IE are immune, but this new vulnerability is still bad news for Windows XP users and earlier since they cannot upgrade to more recent versions of Microsoft?s browser.

?We are actively investigating reports of a small, targeted issue affecting Internet Explorer 6-8,? Dustin Childs of Microsoft Trustworthy Computing told TNW. ?We will take appropriate action to help keep customers protected once our analysis is complete. People using Internet Explorer 9-10 are not impacted.?

The IE zero-day flaw first came to light after report surfaced that the Council on Foreign Relations (CFR) had been hacked. A closer look by security firm FireEye led to the discovery that the CFR site had been compromised and was hosting malicious content as early as on December 21.

?The Council on Foreign Relations? website security team is aware of the issue and is currently investigating the situation,? CFR spokesperson David Mikhail told The Washington Free Beacon on Thursday. ?We are also working to mitigate the possibility for future events of this sort.?

The malicious JavaScript in question only served the exploit code to browsers whose language was either English (U.S.), Chinese (China), Chinese (Taiwan), Japanese, Korean, or Russian. Once the initial checks passed, the JavaScript proceeded to load an Adobe Flash file named ?today.swf.? This file ultimately triggered a heap spray in IE and downloaded a file named ?xsainfo.jpg.?

More details of the vulnerability are available at the CERT Knowledgebase ( VU#154201). Here?s the full technical description:

Microsoft Internet Explorer contains a use-after-free vulnerability in the mshtml CDwnBindInfo object. Specially-crafted JavaScript can cause Internet Explorer to create a CDoc object that contains a CDwnBindInfo object. This object may be freed without removing its pointer, resulting in a state where Internet Explorer may attempt to CALL an invalid memory address. Combined with heap spraying or other techniques, an attacker may be able to place arbitrary code at this address. This vulnerability is currently being exploited in the wild, using Adobe Flash to achieve a heap spray and Java to provide Return Oriented Programming (ROP) gadgets.

Since there is no patch available, the note recommends a few workarounds: use the Microsoft Enhanced Mitigation Experience Toolkit (EMET), disable the Flash ActiveX control in IE, and disable Java in IE. We recommend avoiding the use of IE8 or earlier by either upgrading to IE9/IE10, or simply using a different browser such as Google Chrome.

Image credit: Miguel Saavedra

Source: http://feedproxy.google.com/~r/TheNextWebPortugal/~3/0m958iw-j9A/

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Automotive Service Technician Education For A New Profession ...

If you are looking for a Profession in auto repair, you will soon discover that automotive service technician Instruction is provided in trade schools, vocational schools and community colleges across the nation. Automotive service technician Instruction is ideal for these who appreciate utilizing their minds to resolve issues, and do not mind obtaining their hands dirty.

These days?s automotive repair expert should be much more than just an auto mechanic; they have to be nicely-trained specialists with solid Education in automotive service and repair and a lot of hands-on encounter. With the correct background and certified auto service Coaching, you may soon have the title of specialist automotive service technician.

The moment you start your automotive service technician Education, you will discover considerably far more than the essentials of vehicle upkeep and auto repair. A thorough automotive service technician course have to touch upon communications and organization practices, which will be specially valuable need to you make a decision to go into company for oneself.

Your practical Coaching will cover the specialized makes use of for electronic diagnostic gear, laptop or computer-based technical reference supplies, diagnostic computers and compression gauges. You will find out how diagnose the supply of engine or electrical dilemma(s) in automobiles, trucks, buses, and motorcycles, and accurately make a decision the variety of repairs essential. The auto service technician course will teach you to execute upkeep and repairs with classic hand tools, including screwdrivers, pliers, and wrenches, as effectively as power tools, specialized computers and hydraulic gear.

To reach the level of certified automotive service technician can take up to a year of study and practical knowledge. Some automotive service technician schools offer you an advanced two-year associate degree system, which would be quite useful Once in search of employment immediately after graduation. The moment you are a certified automotive repair technician, you will be topic to standard critique and recertification. You must be able to depend on your school update their curriculum to keep existing with emerging technologies, and to periodically provide refresher courses for operating technicians.

If you assume you are prepared to start automotive service repair Education, the very first step is to be certain that your selected school provides Automotive Service Excellence (ASE) Certification. ASE Certification assures that your school will provide you with Coaching that is complete and of high high quality.

To understand a lot more about automotive service technician Instruction, or even on-line automotive Education, go to our web site and submit a request to a couple of schools nowadays. You will soon be on your way to a new vocation in auto service and repair.

DISCLAIMER: Above is a Common OVERVIEW and might or could not reflect particular practices, courses and/or services related with ANY ONE certain school(s) that is or is not advertised on our site.

Copyright 2007 ? All rights reserved by Media Sure Communications, Inc.

Notice: Publishers are totally free to use this post on an ezine or site, supplied the write-up is reprinted in its entirety, such as copyright and disclaimer, and ALL hyperlinks stay intact and active.

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Obama wants gun violence measures passed in 2013

WASHINGTON (AP) ? Recalling the shooting rampage that killed 20 first graders as the worst day of his presidency, President Barack Obama pledged to put his "full weight" behind legislation aimed at preventing gun violence.

Obama voiced skepticism about the National Rifle Association's proposal to put armed guards in schools following the Dec. 14 tragedy at Sandy Hook Elementary School in Newtown, Conn. The president made his comments Saturday in an interview that aired Sunday on NBC's "Meet the Press."

Instead, the president vowed to rally the American people around an agenda to limit gun violence, adding that he still supports increased background checks and bans on assault weapons and high-capacity bullet magazines. He left no doubt it will be one of his top priorities next year.

"It is not enough for us to say, 'This is too hard so we're not going to try,'" Obama said.

"I think there are a vast majority of responsible gun owners out there who recognize that we can't have a situation in which somebody with severe psychological problems is able to get the kind of high capacity weapons that this individual in Newtown obtained and gun down our kids," he added. "And, yes, it's going to be hard."

The president added that he's ready to meet with Republicans and Democrats, anyone with a stake in the issue.

The schoolhouse shootings, coming as families prepared for the holidays, have elevated the issue of gun violence to the forefront of public attention. Six adult staff members were also killed at the elementary school. Shooter Adam Lanza committed suicide, apparently as police closed in. Earlier, he had killed his mother at the home they shared.

The tragedy immediately prompted calls for greater gun controls. But the NRA is strongly resisting those efforts, arguing instead that schools should have armed guards for protection. Some gun enthusiasts have rushed to buy semiautomatic rifles of the type used by Lanza, fearing sales may soon be restricted.

Obama seemed unimpressed by the NRA proposal. "I am skeptical that the only answer is putting more guns in schools," he said. "And I think the vast majority of the American people are skeptical that that somehow is going to solve our problem."

The president said he intends to press the issue with the public.

"The question then becomes whether we are actually shook up enough by what happened here that it does not just become another one of these routine episodes where it gets a lot of attention for a couple of weeks and then it drifts away," Obama said. "It certainly won't feel like that to me. This is something that - you know, that was the worst day of my presidency. And it's not something that I want to see repeated."

Separately, a member of the president's cabinet said Sunday that rural America may be ready to join a national conversation about gun control. Agriculture Secretary Tom Vilsack said the debate has to start with respect for the Second Amendment right to bear arms and recognition that hunting is a way of life for millions of Americans.

But Vilsack said Newtown has changed the way people see the issue. "I really believe that this is a different circumstance and a different situation," Vilsack said on CNN.

Vilsack said he thinks it's possible for Americans to come together. "It's potentially a unifying conversation," he said. "The problem is that these conversations are always couched in the terms of dividing us. This could be a unifying conversation, and Lord knows we need to be unified."

Besides passing gun violence legislation, Obama also listed deficit reduction and immigration as top priorities for 2013. A big deficit reduction deal with Republicans proved elusive this month, and Obama is now hoping Senate Democratic and Republican leaders salvage a scaled-back plan that avoids tax increases for virtually all Americans.

In addition, he issued a defense of former Republican Sen. Chuck Hagel of Nebraska, who has been mentioned as one of the leading candidates to replace Leon Panetta as defense secretary.

Hagel supported the 2002 resolution approving U.S. military action in Iraq, but later became a critic of the war. He has been denounced by some conservatives for not being a strong enough ally of Israel. Also, many liberals and gay activists have banded against him for comments he made in 1998 about an openly gay nominee for an ambassadorship.

Obama, who briefly served with Hagel in the Senate, stressed that he had yet to make a decision but called Hagel a "patriot."

Hagel "served this country with valor in Vietnam," the president said. "And (he) is somebody who's currently serving on my intelligence advisory board and doing an outstanding job."

Obama noted that Hagel had apologized for his 14-year-old remark on gays.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-12-30-Obama/id-87671019340b4afb81a86614aa509d20

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Singing a different tax tune? ? Business Management Daily: Free ...

Q. I?ve invested thousands of dollars in sound systems, instruments and equipment for my band. Can I use the expenses in past years to offset income in 2012? D.B., via email

A. It depends on whether your activity was enough to rise to the level of a business. If it did, you can generally carry back a net operating loss (NOL) for two years and then forward for up to 20 years. You can elect to forgo the carryback period and carry a loss forward, but you must make a timely election on the tax return for the year of the loss.

Tip: On the other hand, the rules are less favorable for an activity treated as a hobby. Expenses are deductible only up to the amount of the hobby income. In other words, you can?t claim a tax loss from a hobby activity.

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Source: http://www.businessmanagementdaily.com/33835/singing-a-different-tax-tune

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Two of Israel's most precious national institutions have fallen to Likud hysteria

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Woman in custody in NYC subway shoving death

NEW YORK (AP) ? A woman is in custody in the death of a man who was shoved in front of a speeding subway train, and she "made statements implicating herself," New York City police said Saturday.

Detectives questioned her but aren't releasing the 31-year-old suspect's name until she is formally charged, NYPD spokesman Paul Browne said in a brief statement. Among other things, investigators were arranging for witnesses to positively identify the woman in custody as the attacker, police said.

Sunando Sen, a 46-year-old Queens resident who was born in India and ran a printing shop, died Thursday night when a woman who had been muttering to herself on a train platform in Queens suddenly knocked him on the tracks as a train entered the station.

The woman fled after the attack. Police released security camera video showing her running from the station.

The attack was the second time this month that someone was pushed to their death in a New York City subway station. A homeless man was arrested in early December and accused of shoving a man in front of a train in Times Square. He is awaiting trial, and claimed he acted in self-defense.

Further details on how police managed to identify the suspect in Sen's death were not immediately available.

Investigators had been following up on tips from people who had seen the security video and were checking homeless shelters and psychiatric units in an attempt to identify the woman.

It was unclear whether she had any connection to Sen. Witnesses told police the two hadn't interacted on the platform as they both waited for the train.

___

Information from: New York Post, http://www.nypost.com

Source: http://news.yahoo.com/woman-custody-nyc-subway-shoving-death-181523192.html

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Edward Deeds, Outsider Artist, Leaves Behind Hauntingly Innocent Drawings From Mental Institution (PHOTOS, INTERVIEW)

"The artist really should be lost to history, and certainly these drawings should," said curator Tom Parker of his unusual and mysterious upcoming exhibition. The exhibited works are by outsider artist Edward Deeds, a mental patient at a Nevada, Missouri?s State Hospital for almost 40 years.

Deeds, who was diagnosed with dementia praecox and schizophrenia, was committed to a mental institution in 1936. Beyond this fact we know little about Deeds' condition, personality or life, although curator Parker sees all he needs to in Deeds' artwork. "The images have one fabulous clue on every page," Parker explained. "State Lunatic Asylum, written on the paper by the hospital. One poetic detail which encapsulates everything you need to know about the artist and his circumstance."

Deeds' drawings, crafted on the official hospital stationary, radiate a remarkable innocence given the circumstances of their creation. Whimsical lions, wide-eyed characters and vintage vehicles comprise a pictorial land far beyond the mental facility walls. The only reminder of Deeds' dark reality is recurrence of the letters ?ECT,? a likely acronym for the controversial shock treatment known as electroconvulsive therapy.

At the time of Deeds' death he gave his collection of drawings to his mother, who passed them to her other son who stored them in his attic. Years later the drawings were tossed out to a curbside junk pile when they were miraculously stumbled upon by a fourteen-year-old boy who became fascinated with Deeds' details. He kept the works safe for 36 years.

The precious drawings, both unpretentious and cryptic, present an idyllic vision from a mysterious perspective. The story of their creation and survival is as magnetic as the raw emotion in his innocent crayon strokes. Thirty of Deeds' works will show at Hirschl & Adler Modern early next year.

Talisman of the Ward: The Album of Drawings by Edward Deeds will show from January 10 until February 9, 2013 at Hirschl & Adler Modern.

• Talisman of the Ward: The Album of Drawings by Edward Deeds Image courtesy Hirschl & Adler Modern

• Talisman of the Ward: The Album of Drawings by Edward Deeds Image courtesy Hirschl & Adler Modern

• Talisman of the Ward: The Album of Drawings by Edward Deeds Image courtesy Hirschl & Adler Modern

• Talisman of the Ward: The Album of Drawings by Edward Deeds Image courtesy Hirschl & Adler Modern

• Talisman of the Ward: The Album of Drawings by Edward Deeds Image courtesy Hirschl & Adler Modern

• Talisman of the Ward: The Album of Drawings by Edward Deeds Image courtesy Hirschl & Adler Modern

• Talisman of the Ward: The Album of Drawings by Edward Deeds Image courtesy Hirschl & Adler Modern

• Talisman of the Ward: The Album of Drawings by Edward Deeds Image courtesy Hirschl & Adler Modern

• Talisman of the Ward: The Album of Drawings by Edward Deeds Image courtesy Hirschl & Adler Modern

• Talisman of the Ward: The Album of Drawings by Edward Deeds Image courtesy Hirschl & Adler Modern

• Talisman of the Ward: The Album of Drawings by Edward Deeds Image courtesy Hirschl & Adler Modern

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2012/12/29/edward-deeds-outsider-art-mental-institution_n_2370637.html

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Tired Of Carrying Your Own Golf Clubs? You Need CaddyTrek, The Robotic Caddy

Tired of those long, arduous days on the golf course? Wish there were some way to ease the burden of having to carry all those golf clubs while your friends rest comfortably in their cubicles at work? CaddyTrek is the robot for you.

Made by FTR Systems, CaddyTrek is basically a golf bag that follows you around. The ?robotic golf club carrier? responds to a pre-programmed gesture, such as a Tiger Woods fist pump, to gear up and follow a golfer through finely buzzed greens or even tall grass. It can travel up to 27 holes on a single charge, manage inclines up to 30 degrees and, for those with a pathological love of the game, this caddy can even trek through snow. CaddyTrek follows six paces behind the golfer, zeroing in on a homing beacon worn on the belt.

?Most people just stop and stare,? Richard Nagle, CaddyTrek?s North America sales manager told the New York Times. ?They?re not used to this.?

Well, yeah. Not only is the technology new, but I think many golfers without PGA tournament wins will remain content to schlep their bags around for a while given the CaddyTrek?s $1,595 price tag.

The day will come when robots do our laundry, take out the garbage and drive us to work. But robots like CaddyTrek and iRobot?s household pioneer worker Roomba are the straightforward robotic applications that will pave the way for their more sophisticated progeny.

PGA rules currently prevent professional golfers from taking a load off with the robotic caddy, but amateurs with the means will no doubt spring for the CaddyTrek just to make their day of leisure a whole lot more leisurely. And they?ll surely welcome standing out on the course, even if it?s not because of their play.

Source: http://singularityhub.com/2012/12/29/tired-of-carrying-your-own-golf-clubs-you-need-caddytrek-the-robotic-caddy/

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Boynton helps No. 14 Florida beat Air Force 78-61

Florida's Patric Young, center, and Air Force's Kyle Green, left and Kamryn Williams wait for a rebound during the second half Saturday, Dec. 29, 2012, in Sunrise, Fla. Florida won 78-61.

ASSOCIATED PRESS

Published: Saturday, December 29, 2012 at 8:33 p.m.

Last Modified: Saturday, December 29, 2012 at 8:33 p.m.

SUNRISE ? Reviewing recent games and watching shot after shot clank off the rim, Kenny Boynton decided to wait until he was open before trying to shake his slump.

With that, the ball started falling. Boynton made three 3-pointers in the second half, when No. 14 Florida pulled away to beat Air Force 78-61 on Saturday in the second game of the Orange Bowl Basketball Classic.

Boynton had made only 4 of 32 from 3-point range over the previous five games, and coach Billy Donovan advised a change in his approach.

?I spent a lot of time watching film with coach Donovan on the shots I?ve been taking,? Boynton said. ?I just tried to take open ones. That?s what I tried in the second half.?

The senior made three 3s in a span of 8 minutes to break the game open. It was likely Boynton?s final college game in his native South Florida, and 20 relatives and friends cheered him on.

?I felt good, coming out and playing an all-around good game,? he said.

The Gators (9-2) used their superior size and smothering defense to grind down the Falcons, who shot 48 percent in the first half and 33 percent in the second half.

?A very good Florida team, and we knew that coming in,? Air Force coach Dave Pilipovich said. ?We got a little worn down in the second half, and that was because of our physical stature compared to theirs.?

The Gators scored 38 points in the paint and had a 36-25 advantage in rebounds against Air Force (8-3), which fell to 2-77 against ranked teams.

Florida State beat Tulsa 82-63 in the first game of the one-day event.

Boynton, who ranks third in career 3-pointers made at Florida with 282, went 3 for 7 from long range and scored 14 points.

?It was good to see the ball go in,? Donovan said. ?This is not the first time he has gone through something like this. I?ve always told him when he?s having a tough time shooting, the biggest thing he can do is take good available shots. When he makes a couple, then he can start taking a little more difficult shots, because he?s in that rhythm.?

Florida?s Erik Murphy scored 21 points, had seven rebounds and added four assists while missing only two shots in 29 minutes. He was chosen the game?s MVP.

?Today was really a complete game for him,? Donovan said. ?He scored in a lot of different ways.?

The Falcons matched the second-best start in school history in their first 10 games but hadn?t faced a team of Florida?s caliber. Air Force?s Michael Lyons was held to 11 points, nine below his average, and he shot only 3 for 14.

Three-point shooting kept the Falcons in the game. They went 9 for 20 from beyond the arc against a team ranked third in the nation in scoring defense.

?We knew coming in they were a good shooting team,? Murphy said. ?They shoot 3s from all five spots. They were hitting 3s in the first half, and at halftime, coach said we have to guard the 3-point line better. I think we did a better job of that in the second half.?

In the second half, the Gators scored 45 points and shot 70 percent.

?We were making better reads and better decisions,? Donovan said.

The Falcons forced Florida to be creative on offense early. The Gators? Scottie Wibekin, inbounding under his basket, bounced a pass off a defender?s back, stepped onto the court and caught the ball for a wide-open layup.

Boynton sparked a 12-3 spurt when he made two 3-pointers and fed Casey Prather for a layup, putting Florida ahead 47-37. Boynton hit another 3 for a 59-47 lead.

The Falcons hit three early 3-pointers to go up 10-5, but that turned out to be their biggest lead. Florida surged ahead, gave up eight consecutive points to fall behind 27-25, then went ahead to stay on a basket by Mike Rosario shortly before halftime.

Source: http://www.heraldtribune.com/article/20121229/wire/121229691

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How The Africa Cup of Nations affects the Premier League and Football League - Group A review

Angola, Cape Verde, Morocco and hosts South Africa are in Group A of the African Cup of Nations and their involvement has either directly or indirectly affected teams such as Everton, Crystal Palace, Oldham Athletic, Norwich City, QPR, Arsenal, Liverpool, Aston Villa, Tottenham Hotspur and Wrexham.

Next year the African Nations Cup is once again in full flow as Zambia look to defend their title in South Africa. As always the competition will have an effect on global football as many stars players from the bigger leagues consider joining up with their countries in a bid to become kings of their home continent.

The Confederation of African Football has set the deadline for the submission of squads for January 9^th; with the full list of 23-players being named by midnight. Any late submissions will see a substantial fine and the loss of a player from the list.

Some teams have announced their preliminary squads or training camp teams early but this of course doesn?t cater for the English League system whose continued lack of a winter break means most of the English based players will not be available until shortly before the competition starts on the 19^th January.

But which Premier League and football league teams are going to win and lose from the Africa Cup of Nations?

Here is a country-by-country guide for Group A.

South Africa

Unless there is a dramatic U-turn from recent international retiree Everton midfielder Steven Pienaar the Premier League should remain largely unaffected by the host nation?s squad choices. Lower down the football pyramid however and Crystal Palace could be without midfield enforcer Kagisho Dikgacoi and Oldham Athletic could lose Dean Furman to the Bafana Bafana. Norwich City winger Andrew Surman is also eligible but has made his intentions clear that he will not play for the country of his birth.

Angola

No current Premier League interest however former Manchester United and Hull City striker Manucho will be looking to add to his impressive goal record for the Palancas Negras.

Morocco

Interestingly The Atlas Lions qualification could have had a bigger impact on the Premier League than is being felt.?Adel Taarabt is not selected for the squad; the?QPR player had given mixed signals as to whether he would accept a call-up, but there are others who have been.?Oussama Assaidi and Karim El Ahmadi of Liverpool and Aston Villa respectively are in, but?Maraoune Chamakh of Arsenal has also not been selected

Cape Verde

The shock qualifiers from the tiny archipelago nation do not have any current players who play in the UK. However their effect is still felt in the Premier League as they qualified at the expense of Cameroon. That means the likes of QPR defender Stephane M?Bia, Tottenham full-back Benoit Assou-Ekotto, Norwich defender Sebastian Bassong and Wrexham goalie Joslain Mayebi will not be lost at the turn of the year.

Who do you think loses out most from the 2013 African Cup of Nations?

image: ? wonker

Mathew Nash

@MathewNash89more stories from Mathew Nash

I?m Mathew Nash a 23 year old graduate in Sports Studies and I have an insatiable love for sport. With a particularly keen interest for the madcap world of football I have always been known amongst friends as a beacon for bizarre sporting trivia and knowledge. My other passion is for writing and hopefully combining the two will create a superb and entertaining marriage that will create, divide and share opinion.

Source: http://hereisthecity.com/2012/12/21/mn-how-afcon-2013-affects-the-premier-league-group-a-review/

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South Africa: Nelson Mandela convalesces at home

by Associated Press Associated Press

JOHANNESBURG (AP) ? South Africa's presidency says it has no updates on the condition of former leader Nelson Mandela, who is convalescing at home after a hospital stay and is reported to be doing better.

The South African Press Association quotes presidential spokesman Mac Maharaj as saying Saturday that he has no new information on 94-year-old Mandela, who was released from a hospital on Wednesday. The former president, who spent 27 years in prison under apartheid, was admitted Dec. 8 and received treatment for a lung infection.

He also had a procedure to remove gallstones.

Maharaj previously said doctors have noted progress in Mandela's condition but will continue to treat him at his home in the Johannesburg neighborhood of Houghton.

Source: http://romenews-tribune.com/bookmark/21270279

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DHA to regulate services provided through health insurance | Dubai ...

This will be done through the implementation of a regulatory framework as well as electronic insurance claims, aiming to further improve the quality of services provided in Dubai and insure that nationals and residents are protected in a sustainable health system.

Registration of insurance providers:
Dr Haidar Al Yousuf, Director of Health Funding for the DHA, said, "This means that all insurance companies will be registered by the authority and that the authority will take on an inspectional role to ensure all providers are following protocols to provide best insurance services to their customers."

Insurance policy holders' will have a channel to lodge their feedback, suggestions and complaints. Regulating health insurance policies also means that the DHA will ensure that the policy holder's are getting insurance for all the services they are entitled to as per their policy.

E-claims system to lodge all health claims electronically:
Moreover, every health insurance claim in the Emirate of Dubai, will be lodged online through the e-claims portal which is already in place. The portal will provide a complete break-down of the insurance claims which is a significant leap for the health sector in Dubai.

This means that, we will be able to get a detailed range of gold-standard data such as break-up of claims according to health specialties in the Emirate of Dubai. E.g: No of people who visited the practitioner for cardiac problems, diabetes etc in 2013.

This information will help the DHA study healthcare pattern which in the long run, is a process that will substantially aid in setting public health policies and strategies to ensure better health for the population of Dubai."

Regulating the services provided by insurance companies is an essential stage within the universal coverage mandate as highlighted by the Dubai Strategic Plan 2015, as envisioned by His Highness Sheikh Mohammad Bin Rashid Al Maktoum, Vice-President and Prime Minister of UAE and Ruler of Dubai.

The authority will also regulate price increases by private providers as well as insurance premiums based on inflation parameters and best practice models in health insurance, the authority's role will ensure establishing the correct balance to drive further investment to the health sector and the ensure long-term sustainability of health services without any parties making exaggerated profits that could be damaging to beneficiaries, employers and the economy.

Dr Al Yousuf elaborated that health insurance is a dynamic growing sector with close to 40 insurance companies and many self insured schemes providing health insurance coverage to around one million members in Dubai and that regulating and monitoring this sector is fundamental to protect members, limit attempts of abuse and further enhance the quality and sustainability of health services in the Emirate.

He announced that the DHA Director-General has instructed to expedite the role out of the framework to be functional within the first quarter of 2013.

Source: http://www.ameinfo.com/dha-regulate-services-provided-health-insurance-324148

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Jennifer Aniston & Justin Theroux Are Sizzling in Cabo!

Jennifer Aniston soaks up the sun with her hard-bodied fiance! Check out more pics of Hollywood's tightest twosomes

Source: http://www.ivillage.com/star-snapshots-celebrity-couples-photos-2012/1-b-469173?dst=iv%3AiVillage%3Astar-snapshots-celebrity-couples-photos-2012-469173

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Top 25 Best 3DS Games of 2012 - Video Games Blogger

The Top 25 best 3DS games of 2012 have been revealed! Is your favorite 3DS game part of the list of the greatest the Nintendo 3DS & DS handhelds had to offer in 2012? The year is almost over, so we?ve compiled this list of the top-quality AAA must-own titles of the year!

Index of Top 25 Best Games of 2012 Lists:

We?ve included the few top DS games there were this year in this 3DS list, since the 3DS is backwards compatible with all DS games.

Is there a game that didn?t make the list, that you think deserves a spot? Leave a comment and let us know your own list!

Runners-Up:

Marvel Pinball 3D, Sakura Samurai: Art of the Sword (3DS Exclusive), Zuma?s Revenge! (DS Version; Plays On 3DS), Fractured Soul (3DS Exclusive), Pro Evolution Soccer 2012 3D, LEGO Batman 2: DC Super Heroes, Order Up!!, Rayman Origins (3DS Version), Aero Porter, and CRUSH3D (3DS Version).

#25 ? Harvest Moon 3D: A New Beginning (3DS Exclusive)
#24 ? Paper Mario: Sticker Star (3DS Exclusive)
#23 ? Kingdom Hearts 3D: Dream Drop Distance (3DS Exclusive)
#22 ? Tales of the Abyss (3DS Version)
#21 ? Crimson Shroud (3DS Exclusive)
#20 ? Rhythm Thief & the Emperor?s Treasure
#19 ? Ketzal?s Corridors (3DS Exclusive)
#18 ? New Super Mario Bros. 2 (3DS Exclusive)
#17 ? Metal Gear Solid: Snake Eater 3D
#16 ? Theatrhythm Final Fantasy
#15 ? ZEN Pinball 3D
#14 ? The Denpa Men: They Came By Wave (3DS Exclusive)
#13 ? Transformers Prime: The Game
#12 ? Mutant Mudds
#11 ? Shin Megami Tensei: Devil Survivor 2 (DS Exclusive; Plays On 3DS)

#10 ? Pokemon Conquest (DS Exclusive; Plays On 3DS)

#9 ? Art Academy: Lessons for Everyone (3DS Exclusive)

#8 ? NightSky

#7 ? Art of Balance Touch! (3DS Exclusive)

#6 ? Pokemon Black & White Version 2 (DS Exclusive; Plays On 3DS)

Find out which 3DS game is #1 in 2012 as our countdown continues on the next page?

Continue Reading on: Page 1 Page 2

About the author

By Ferry Groenendijk: He is the founder and editor of Video Games Blogger. He loved gaming from the moment he got a Nintendo with Super Mario Bros. on his 8th birthday. Learn more about him here and connect with him on Twitter, Facebook and at Google+.

Source: http://www.videogamesblogger.com/2012/12/28/top-25-best-3ds-games-of-2012.htm

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