Sunday, September 30, 2012

Online Social Media: Entrepreneurs' Tips

Any properly-organized, constant and lasting social media campaign is a vital part of a completely integrated web marketing strategy. Today, the highly complicated strategy of developing a site as well as optimising it efficiently to successfully gain a high search engine results position is not really adequate. A portion of your own campaign also needs to involve establishing a strong appeal throughout major online social network websites.

Even so, it is not as simple as merely beginning a Facebook account. From start-up organizations focusing on brand awareness to well-recognized organizations wanting to preserve if not enhance their prime rank, each business which begins into a marketing strategy within a social networking site should look for the assistance of experts. Promoting over online social media, business people know, demands as much concentration and tactical preparation as other standard media marketing strategies.

Sometimes, a straightforward, linear strategy can be successful in a social media promotion. A common model is a contest in which people are required to provide pictures which include the product or company getting marketed. The presented picture having the most number of votes (or perhaps ?likes?) gets fantastic rewards. To successfully win, people will naturally pass information regarding the actual event and also the brand to their group of associates, their friend?s friends, and also to more circles of influence. The goal of the marketing strategy is to improve their range to a broader base can then be achieved.

The issue with this method is that brand recall will last simply as long as the voter clicks on ?like,? particularly if it wasn?t thoroughly prepared or followed through. The absolutely successful social networking campaign method is something that is reinforced with an innovative as well as specialized structure. It should be built to complement the nature of your company, your brand image as well as your particular business targets. This is often particularly true to products or services which have to convince its public initially, like a health brand which requires a disciplined lifestyle or a product which replaces more recognized or known alternatives.

A successful social media campaign can certainly aid a business to be able to convert the involvement of social media users into actual income. However, the finest social media marketing strategy-the enduring and high-impact ones-knows that improved sales isn?t the be-all and end-all of the full effort. The power of social media websites is that they provide a podium for simple, direct and engaged connection with your target market. Work with that power to interact with your clients-sustain a dialogue with these people, discover much more about their requirements, search for the other areas in which you can offer solutions for them. In the process, you can eventually uncover different ways to serve these people better-the main quality of a credible as well as reliable company name.

Need assistance with marketing your company through social media? London experts will always be there to help you.

Source: http://ninjaseomethods.com/online-social-media-entrepreneurs-tips/

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Common RNA pathway found in ALS and dementia

ScienceDaily (Sep. 30, 2012) ? Two proteins previously found to contribute to ALS, also known as Lou Gehrig's disease, have divergent roles. But a new study, led by researchers at the Department of Cellular and Molecular Medicine at the University of California, San Diego School of Medicine, shows that a common pathway links them.

The discovery reveals a small set of target genes that could be used to measure the health of motor neurons, and provides a useful tool for development of new pharmaceuticals to treat the devastating disorder, which currently has no treatment or cure.

Funded in part by the National Institutes of Health and the California Institute for Regenerative Medicine (CIRM), the study will be published in the advance online edition of Nature Neuroscience on September 30.

ALS is an adult-onset neurodegenerative disorder characterized by premature degeneration of motor neurons, resulting in a progressive, fatal paralysis in patients.

The two proteins that contribute to the disease -- FUS/TLS and TDP-43 -- bind to ribonucleic acid (RNA), intermediate molecules that translate genetic information from DNA to proteins. In normal cells, both TDP-43 and FUS/TLS are found in the nucleus where they help maintain proper levels of RNA. In the majority of ALS patients, however, these proteins instead accumulate in the cell's cytoplasm -- the liquid that separates the nucleus from the outer membrane, and thus are excluded from the nucleus, which prevents them from performing their normal duties.

Since the proteins are in the wrong location in the cell, they are unable to perform their normal function, according to the study's lead authors, Kasey R. Hutt, Clotilde Lagier-Tourenne and Magdalini Polymenidou. "In diseased motor neurons where TDP-43 is cleared from the nucleus and forms cytoplasmic aggregates," the authors wrote, "we saw lower protein levels of three genes regulated by TDP-43 and FUS/TLS. We predicted that this, based on our mouse studies, and found the same results in neurons derived from human embryonic stem cells."

In 2011, this team of UC San Diego scientists discovered that more than one-third of the genes in the brains of mice are direct targets of TDP-43, affecting the functions of these genes. In the new study, they compared the impact of the FUS/TLS protein to that of TDP-43, hoping to find a large target overlap.

"Surprisingly, instead we saw a relatively small overlap, and the common RNA targets genes contained exceptionally long introns, or non-coding segments. The set is composed of genes that are important for synapse function," said principal investigator Gene Yeo, PhD, assistant professor in the Department of Cellular and Molecular Medicine and the Institute for Genomic Medicine at UC San Diego and a visiting professor at the Molecular Engineering Laboratory in Singapore. "Loss of this common overlapping set of genes is evidence of a common pathway that appears to contribute to motor neuron degeneration."

In an effort to understand the normal function of these two RNA binding proteins, the scientists knocked down the proteins in brains of mice to mimic nuclear clearance, using antisense oligonucleotide technology developed in collaboration with ISIS Pharmaceuticals. The study resulted in a list of genes that are up or down regulated, and the researchers duplicated the findings in human cells.

"If we can somehow rescue the genes from down regulation, or being decreased by these proteins, it could point to a drug target for ALS to slow or halt degeneration of the motor neurons," said Yeo.

These proteins also look to be a central component in other neurodegenerative conditions. For example, accumulating abnormal TDP-43 and FUS/TLS in neuronal cytoplasm has been documented in frontotemporal lobar dementia, a neurological disorder that has been shown to be genetically and clinically linked to ALS, and which is the second most frequent cause of dementia after Alzheimer's disease.

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The above story is reprinted from materials provided by University of California - San Diego, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Clotilde Lagier-Tourenne, Magdalini Polymenidou, Kasey R Hutt, Anthony Q Vu, Michael Baughn, Stephanie C Huelga, Kevin M Clutario, Shuo-Chien Ling, Tiffany Y Liang, Curt Mazur, Edward Wancewicz, Aneeza S Kim, Andy Watt, Sue Freier, Geoffrey G Hicks, John Paul Donohue, Lily Shiue, C Frank Bennett, John Ravits, Don W Cleveland, Gene W Yeo. Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nature Neuroscience, 2012; DOI: 10.1038/nn.3230

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/25QVm4Je7AQ/120930142108.htm

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Crustaceans hide their true age in stomach

THE way to a lobster's age is through its stomach. The finding could improve our understanding of mortality rates within lobster populations, with implications for sustainable fishing practices.

Aquatic species are usually aged by counting annual growth bands deposited on hard parts in their bodies - like counting tree rings. Many fish have bands on bones in the ear, but crustaceans lose their hard parts when they moult.

Raouf Kilada at the University of New Brunswick in Canada has found a lobster hard part that isn't lost - the gastric mills that grind its food. He presented the finding at the Crustacean Society meeting in Athens, Greece, in June.

Scientists use body size to approximate crustacean age in population models. Kilada's work could make the models more precise, says Adrian Linnane at the South Australian Research and Development Institute.

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Kate joins family at society wedding as her father walks another bride up the aisle for friend's marriage

  • Kate, sister Pippa, and parents Carole and Michael attended the wedding of Thierry Kelaart and Patrick Heathcote-Amory in Oxfordshire
  • Michael Middleton gave the bride away at the ceremony in St Bartholomew's Church near Henley-on-Thames

By Kerry Mcdermott

|

More than a year has passed since Kate Middleton's father Michael walked her up the aisle to meet her groom Prince William.

Today the Duchess of Cambridge watched her father give away another beautiful bride as the Middleton family attended a society wedding.

Michael Middleton walked family friend Thierry Kelaart into St Bartholomew's church and down the aisle, standing in for her late father.

Sophisticated: The Duchess of Cambridge chose a pale blue knee-length dress and her trademark nude heels for the wedding, while sister Pippa wore a beige dress topped off with a jacket and matching fascinator

The elegant brunette tied the knot with groom Patrick Heathcote-Amory, a relative of Tory politician David Heathcote-Amory - whose career was marred by an expenses scandal in which he billed the cost of manure to the taxpayer.

Kate and Pippa looked glamorous as they watched the Church of England ceremony and the sounds of Glory Hallelujah could be heard ringing as the couple wed.

After the ceremony Kate's mother, Carole Middleton, led her daughters through a side door surrounded by other guests while the bride and groom stood in the entrance at the back of the church.

Kate Middleton's father Michael Middleton gave bride Thierry Kelaart away at the wedding

Kate Middleton's father Michael Middleton gave bride Thierry Kelaart away at the wedding

Fresh from her tour of Southeast Asia with husband Prince William, the Duchess of Cambridge wore a striking hat at the wedding of family friend Thierry Kelaart

Fresh from her tour of Southeast Asia with husband Prince William, the Duchess of Cambridge wore a striking hat at the wedding of family friend Thierry Kelaart

Smiling Kate appeared eager to avoid the attention of photographers gathered at the church in Oxfordshire, keeping her head lowered beneath her hat

Surrounded by smartly dressed children the happy couple posed for photographs while guests lined the churchyard alongside them, while bells rang out in the background.

The bride and groom and their guests then made their way to a farmhouse next door to the church before other guests joined them and eventually Pippa, dressed in a cream suit jacket over a cream dress, followed.

?

Kate was not far behind as, surrounded by several male pals, she made her way quietly up the dirt path alongside the church building to the reception area.

Dressed elegantly in a long-sleeved turquoise dress, the future Queen turned her hat, positioned at an angle, to a bank of waiting press photographers to hide her face.

Fresh back from her tour of the Far East she appeared shy and reluctant to return to the limelight after the exhausting round of public appearances.

High-profile guests: Kate Middleton's mother Carole wore an elegant pale pink dress and matching jacket, accessorised with a black hat, clutch bag and heels

High-profile guests: Kate Middleton's mother Carole wore an elegant pale pink dress and matching jacket, accessorised with a black hat, clutch bag and heels

Bride and Groom: Elegant bride Thierry Kelaart wore a satin dress with a delicate lace overlay to wed Patrick Heathcote-Amory

Bride and Groom: Elegant bride Thierry Kelaart wore a satin dress with a delicate lace overlay to wed Patrick Heathcote-Amory in Oxfordshire

The Duchess did her best to remain in the background, avoiding upstaging the bride at the picturesque village wedding, in Nettlebed, near Henley-on-Thames, Oxfordshire.

A source at the church said: 'It went very well. The wedding was very well planned and it was a wonderful village occasion.

'As far as I'm aware the Middleton's are very, very old family friends of the bride.'

One wedding guest said: 'The wedding was lovely, absolutely lovely. I don't know why Michael Middleton was chosen to give the bride away but I know her father has passed away.'

?

Source: http://www.dailymail.co.uk/news/article-2210457/Kate-joins-family-society-wedding-father-walks-bride-aisle-friends-marriage.html?ITO=1490

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Carmageddon II raises traffic concerns...to the sky?

The roads were empty during last year's uneventful Carmageddon, but the Los Angeles highway closure had one unexpected hitch: swarms of noisy, sightseeing helicopters.?

By Richard Read,?Guest blogger / September 29, 2012

This July 2011 file photo shows Interstate 405 free of traffic, seen looking south from the Skirball Drive bridge, as the demolition of two lanes Mulholland Drive bridge continue in Los Angeles at dawn. Though the last Carmageddon was uneventful, the air above Los Angeles did become noishy and crowded with helicopters.

Reed Saxon/AP/File

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If you live in Southern California, you probably remember?Carmageddon?-- not the?video game, not the pet name that some gave to the 2008/2009?auto?industry bailout, but?the closure of the 405, one of Los Angeles' busiest highways. Now, it's happening again, and once again, residents are concerned about its impact on their quality of life.

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In July of last year, officials closed a section of the 405 for three days in order to demolish the south side of Mulholland Bridge, a messy but necessary step in a?$1 billion highway improvement project. California officials urged residents who had to drive to stay as far away from the 405 as possible, warning of monumental traffic jams. Citizens panicked, the media predicted complete chaos, and in the end...well, in the end, it wasn't a big deal at all.

In fact, traffic over the Carmageddon weekend was pretty light, and the number of people?using mass transit soared. In fact, Carmageddon was such a non-event that some people began asking?if LA shouldn't promote car-free weekends more often.?

LA being LA, residents quickly resumed their auto-centric habits as soon as Carmageddon wrapped up (17 hours ahead of schedule, thank you very much). But they're going to get the chance to break the 405 habit once more this weekend.

From 7pm today until 5am Monday, the same ten-mile stretch of the 405 will be shut down as?construction?teams -- you guessed it -- demolish the?north?side of the Mulholland Bridge so that it can be rebuilt wider and more seismically sound.

City officials are hoping that Carmageddon II -- which we affectionately dubbed "Carmageddon 2: Revenge of the Fallen: This Time, It's?Electric?Boogaloo (featuring Patty Smyth)"?-- will go as smoothly as the first one. However, some who live near the soon-to-be-closed interstate have a new concern:?traffic jams overhead.

According to the?LA Times,?there was one under-reported hitch in last year's Carmageddon:swarms of sightseers hovering in helicopters?above the Westside neighborhood to catch a glimpse of the Mulholland Bridge's destruction. In fact, the situation was so bad that U.S.?Congressman Howard Berman (D-Valley Village) proposed the?Los Angeles Residential Helicopter Noise Relief Act, which would have allowed the Federal Aviation Administration to set rules governing flight paths for helicopter operators in LA.

Alas, Berman's bill seems to have stalled, so officials are now?asking?insisting that helicopter pilots be considerate and reasonable over the weekend. While news crews will undoubtedly be on hand for the event, Sherman Oaks board director Bob Anderson has demanded that well-heeled gawkers "stop having wine and cheese parties on helicopters to watch the bridge come down."

Live in LA? What are your plans for the weekend? Will you find alternative fun to pass the time like?Artmageddon, or will you ignore Anderson's request and take to the skies?

The Christian Science Monitor has assembled a diverse group of the best auto bloggers out there. Our guest bloggers are not employed or directed by the Monitor and the views expressed are the bloggers' own, as is responsibility for the content of their blogs. To contact us about a blogger,?click here.?To add or view a comment on a guest blog, please go to the blogger's own site by clicking on the link in the blog description box above.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/DNIbd5UIm4w/Carmageddon-II-raises-traffic-concerns-to-the-sky

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Improve annuities Your Personal Finances With These Tips ...

Improve annuities Your Personal Finances With These Tips

Many people feel overwhelmed when they think about improving their finances. However, personal finances don?t have to be complicated or painful. If you take the time to learn where your money is going and figure out where you want it to go instead, you should be able to improve your finances fairly quickly.

If you are trying to repair your credit score, be sure to check your credit report for mistakes. You may be suffering from a credit card company?s computer error. If you notice a mistake, be sure to have it corrected as soon as possible by writing to all of the major credit bureaus.

Even if your home has decreased in value since you bought it, this doesn?t mean you?re doomed to lose money. You don?t actually lose any money until you sell your house, so if you don?t have to sell at the moment, don?t. Wait until the market improves and your property value begins to rise again.

If you are young, ignore the conventional wisdom of investing in 80 percent stocks and 20 annuity rates percent bonds, and instead aim for a 50-50 balance. Given the volatility of the market, you can still lose quite a bit by putting most of your money in stocks. Having a mix of both may reduce your returns a little bit, but it might also cushion you against huge losses.

Check your credit report on a regular basis to make sure that nothing is hurting your credit. Each of the three major credit agencies is required to give you a free credit report once per year. By spacing out your requests, you can get a free credit report every four months.

Don?t let banks use your money for free. Many banks require customers to maintain a high minimum balance to avoid fees for checking or savings accounts, but pay very low or no interest on the amount. You can usually find a better deal at a credit union or an online bank.

To save money on your energy bill, clean te dust off your refrigerator coils. Simple maintenance like this can go a long way in reducing your overall expenses around the house. This easy task will mean that your fridge annuity rates can function at normal capacity with a lot less energy.

Taking a job at a store that carries many thing that are of interest to you can be a great decision. Not only will you earn a paycheck for working at that store, but will also receive an employee discount that can be used to save money on things bought there, providing two benefits to your personal finances.

When you are putting together a family budget, make sure to get all in the family involved including your children. Since money is spent on each family member, having your family?s input on how much they spend and how much to save, a compromise can then be made on a budget. It is easier to stick with a budget when you have a family consensus.

As you?ve just read, personal finances don?t have to be overwhelming. If you take the advice that you have read in this article and run with it, you can turn your financial situation around. Just look honestly at your finances and decide what changes you want to make, so that soon, you can enjoy the benefits of improved finances.


Tags: computer error, losses, stocks

Source: http://warandmoon.com/2012/09/improve-annuities-your-personal-finances-with-these-tips/

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California creates state-run private retirement plan

SACRAMENTO, Calif. (AP) ? California Gov. Jerry Brown signed legislation Friday that will create the nation's first state-administered retirement savings program for private-sector workers, over the objection of critics who said it creates a new liability for taxpayers.

The bill will establish the California Secure Choice Retirement Savings Program for more than 6 million lower-income, private-sector workers whose employers do not offer retirement plans.

The program directs employers to withhold 3 percent of their workers' pay unless the employee opts out of the savings program, which can be done every two years. It would be administered by a seven-member board chaired by the state treasurer. The board would select a professional fund manager, which could be a private investment firm or the state's public pension system, to maintain the money.

State Sen. Kevin De Leon, D-Los Angeles, introduced the bill earlier this year in response to what he called the "looming retirement tsunami" as millions of lower-wage workers face financial hardship in their retirement years. He said the program will act as a supplement to Social Security by offering private-sector workers a portable savings plan with a guaranteed return.

He said the program is not a pension but rather acts as a savings account, which could be a national model for improving retirement savings.

"This is a major step forward for retirement security in America," De Leon said in a statement. "I am grateful for Gov. Brown's acumen and with his leadership we are setting the path for middle class hard-working Americas to prepare for retirement so they won't be forced into poverty."

State Sen. Mimi Walters, R-Lake Forest, called SB1234 the "worst bill to make its way out of the legislature this year" because it would allow the state's main pension system to invest the money.

Walters noted that the California Public Employees' Retirement System is running a shortfall and that the savings program will be controlled by a group of "career politicians."

"SB1234 looks like nothing more than a cynical effort to prop up the floundering public employee pension debt with new funds from private investors," Walters wrote in a blog ahead of the bill signing.

Many cities and counties already pool their contributions along with the state in the public pension system, but taxpayers are on the hook to cover public employee benefits if investment projections fall short.

It's too soon to say what would happen if CalPERS managed the new retirement program, said pension fund's spokesman, Brad Pacheco. CalPERS could create a separate account for private-sector workers, although it's more likely to pool investments with public employees.

CalPERS' fund posted an annual return of just 1 percent last year, missing its own long-term annual target of 7.5 percent. It currently has an estimated long-term unfunded liability of $100 billion.

Democratic lawmakers said the program gives workers more savings options, particularly women working low-paying jobs. Supporters say it will not cost the state money because it will be backed by underwriters and reinsured to protect returns. De Leon noted that the money would be placed into low-risk investments with interest guaranteed at a low rate tied to long-term Treasury bond yields.

Participants would also have to sign a liability waiver stating that California would not be liable for losses.

The bill would not be implemented unless the savings program is projected to be self-sustaining and exempt from federal rules that cover private-sector defined benefit plans. Such plans have to meet minimum standards under the federal Employee Retirement Income Security Act.

The bill also requires the board to submit an annual audit. It was initially opposed by businesses, insurance companies and financial services firms. Business groups such as the California Chamber of Commerce dropped opposition after changes were made to the bill, according to De Leon's staff.

The governor also signed companion legislation under SB923.

Republican lawmakers who opposed the program when it was moving through the Legislature said low-income workers might be better off financially if they put after-tax earnings into a Roth IRA, which would allow them to take their contributions tax-free in retirement.

They also said there were too many unanswered questions about the program. GOP lawmakers said if the underwriter fails to meet investment targets, taxpayers and employers could be held responsible for covering losses and administrative overhead.

Source: http://news.yahoo.com/calif-creates-state-run-private-retirement-plan-232409988--finance.html

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Homes For Sale Downtown Pleasanton CA August 2012 Downtown ...

Homes For Sale Downtown Pleasanton CA August 2012 Downtown Pleasanton CA Real Estate Market Update September 29, 2012 | Homes for Sale in San Ramon, Danville CA, Dublin CA, Pleasanton ?2012 Bay East. ?2012 CCAR. ?2012 EBRD. All rights reserved. Information deemed reliable but not guaranteed. This information is provided from three separate sources: Bay East, CCAR and EBRD. The listings presented here may or may not be listed by the Broker/Agent operating this website. Information last updated on 9/29/12 10:09 PM PDT.

This IDX solution is (c) Diverse Solutions 2012.

Source: http://vickiesellshomes.com/homes-for-sale-downtown-pleasanton-ca-august-2012-downtown-pleasanton-ca-real-estate-market-update-september-29-2012/

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